Paper Published: Confirming the Work of Jamie Andrews through 70 Years of Peer-Reviewed Evidence

The Non-Specificity of Cytopathic Effects

I’m pleased to share the publication of my latest paper: The Non-Specificity of Cytopathic Effects: Implications for Virological Research and Public Health (https://zenodo.org/records/15872332)

This paper is the result of a deep dive into more than 30 historical peer-reviewed studies, many of which have been overlooked or forgotten, that raise critical questions about the reliability of cytopathic effects (CPE) as indicators of viral presence.

Why this matters: In recent years,

Jamie Andrews

’ control experiments challenged the assumption that CPE in cell cultures definitively points to viral replication. His work sparked controversy—but as this new paper shows, his conclusions are not new. They are backed by a rich body of older, peer-reviewed literature from virology’s formative decades (1950s–1980s and beyond), all pointing to the non-specificity of CPE.

The paper documents historical findings where CPE appeared in uninoculated control cultures, often caused by stressors like nutrient deprivation or antibiotic toxicity—not viruses. These findings were known and published, but largely ignored or misattributed in the rush to define viral causality.

Jamie Andrews

’ experiments have now been robustly contextualized and confirmed. This convergence of old and new evidence represents a crucial opportunity to reevaluate foundational assumptions in virology and public health.

I hope this paper helps advance the conversation and encourages more rigorous standards in experimental design, especially where public health decisions are at stake.

Read, share, and comment: https://zenodo.org/records/15872332